2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1786
    Allatostatin II 123374-34-5 98%
    Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.
    Allatostatin II
  • HY-P1787
    β-Amyloid (4-10) 477284-32-5 98%
    β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.
    β-Amyloid (4-10)
  • HY-P1793
    α-Casein (90-95) 83471-50-5 99.51%
    α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer.
    α-Casein (90-95)
  • HY-P1803
    Protein Kinase C Peptide Substrate 120253-69-2 98%
    Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Protein Kinase C Peptide Substrate then regulates various physiological functions including the activation of nervous, endocrine, exocrine, inflammatory, and immune systems.
    Protein Kinase C Peptide Substrate
  • HY-P1805
    Calmodulin Binding Peptide 1 104041-80-7 98%
    Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca2+ release .
    Calmodulin Binding Peptide 1
  • HY-P1817
    PACAP-38 (16-38), human, mouse, rat 144025-82-1 98%
    PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP is a potent activator of cAMP formation.
    PACAP-38 (16-38), human, mouse, rat
  • HY-P1818
    Neuropeptide Y (22-36) 119019-65-7 98%
    Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y2 receptor and retains subnanomolar affinity for the Y2 receptor.
    Neuropeptide Y (22-36)
  • HY-P1819
    N-Acetyl-α-Endorphin 88264-63-5 98%
    N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.
    N-Acetyl-α-Endorphin
  • HY-P1833
    Egg Laying Hormone, aplysia 117680-39-4 98%
    Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron.
    Egg Laying Hormone, aplysia
  • HY-P1851
    AGA-(C8R) HNG17, humanin derivative 875910-01-3 98%
    AGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults.
    AGA-(C8R) HNG17, humanin derivative
  • HY-P1854
    β-Amyloid (1-9) 147529-30-4 98%
    β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism .
    β-Amyloid (1-9)
  • HY-P1858
    Urocortin III, mouse 357952-10-4 98%
    Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
    Urocortin III, mouse
  • HY-P1863
    α-Neoendorphin (1-8) 83339-89-3 98%
    α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.
    α-Neoendorphin (1-8)
  • HY-P1866
    β-Endorphin, equine 79495-86-6 98%
    β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. Analgesic properties.
    β-Endorphin, equine
  • HY-P1867
    β-Amyloid (1-34) 186359-65-9 98%
    β-Amyloid (1-34) is a β-Amyloid peptide consists of 34 amino acid.
    β-Amyloid (1-34)
  • HY-P1869
    Neuropeptide EI, rat 125934-45-4 98%
    Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
    Neuropeptide EI, rat
  • HY-P1874
    Calmodulin-Dependent Protein Kinase II (281-309) 116826-37-0 98%
    Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II).
    Calmodulin-Dependent Protein Kinase II (281-309)
  • HY-P1879
    β-Amyloid (18-28) 112163-49-2 98%
    β-Amyloid (18-28) is a peptide fragment of β-Amyloid.
    β-Amyloid (18-28)
  • HY-P1880
    β-Amyloid (12-20) 134649-29-9 99.84%
    β-Amyloid (12-20) is a peptide fragment of β-Amyloid.
    β-Amyloid (12-20)
  • HY-P1886
    Kv3, Channel Containing Protein (567-585) 98%
    Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons .
    Kv3, Channel Containing Protein (567-585)
Cat. No. Product Name / Synonyms Application Reactivity